Drug and Alcohol - Opioid Addiction

M365 Pill: The Facts About Norco, Vicodin, and M365 Addiction

M365: How this White Oval Pill can be a Gateway into Addiction

M365 is a potent opioid painkiller. When abused, it's possible to get addicted and overdose. Learn more about Norco & Vicodin addiction in our blog!

The M365 pill is a prescription medication used to treat moderate to severe pain. It combines hydrocodone, an opioid pain reliever, with acetaminophen, a non-opioid pain reliever, which changes how your body feels and responds to pain. However, it’s important to be aware that, like all opioids, the M365 pill can lead to tolerance, physical dependence, and addiction if not used as directed.

What Is the M365 Pill?

M365 is a white oval pill with the “M365” imprint which contains 325 mg of acetaminophen and 5 mg of hydrocodone. It’s an opioid and narcotic analgesic prescribed for moderate to severe pain management and manufactured by Mallinckrodt Pharmaceuticals, but due to its patterns of abuse and addiction potential, M365 was reclassified as a Schedule II narcotic in 2014 under the Controlled Substance Act (CSA).Hydrocodone is the opioid analgesic that provides pain relief, while acetaminophen is a non-opioid analgesic that complements the effects of hydrocodone and helps reduce fever. However, hydrocodone also carries high abuse potential.

M365 Pill: What Is it?
M365 Pill: What is the M365 White Oval Pill?
M365 Pill: The Dangers of M365 Abuse
Signs of M365 Abuse
Signs of M365 Overdose
What to do During an M365 Overdose
Is M365 Abuse Treatable?

M365 Pill Brands

The following brands share the same active ingredients as the M365 pill, all combining either hydrocodone or hydrocodone bitartrate with acetaminophen to manage pain:

Norco

Produced by Actavis Pharma, Inc., Norco is a pain relief medication that combines hydrocodone bitartrate and acetaminophen. It’s commonly prescribed to alleviate moderate to severe pain.

  • 325 mg acetaminophen, 5 mg hydrocodone

  • 325 mg acetaminophen, 7.5 mg hydrocodone

  • 325 mg acetaminophen, 10 mg hydrocodone

Vicodin

Vicodin is manufactured by AbbVie Inc. and contains hydrocodone bitartrate and acetaminophen. It’s used to treat moderate to moderately severe pain.

  • 300 mg acetaminophen, 5 mg hydrocodone bitartrate

  • 300 mg acetaminophen, 7.5 mg hydrocodone bitartrate

  • 300 mg acetaminophen, 10 mg hydrocodone bitartrate

Lortab

Made by UCB, Inc., Lortab is a combination of hydrocodone bitartrate and acetaminophen, prescribed for the management of moderate to severe pain.

  • 325 mg acetaminophen, 5 mg hydrocodone bitartrate

  • 325 mg acetaminophen, 7.5 mg hydrocodone bitartrate

  • 325 mg acetaminophen, 10 mg hydrocodone bitartrate

Lorcet

Lorcet is manufactured by Mayne Pharma Inc., includes hydrocodone bitartrate and acetaminophen, and is prescribed for moderate to severe pain management.

  • 325 mg acetaminophen, 5 mg hydrocodone bitartrate

  • 325 mg acetaminophen, 7.5 mg hydrocodone bitartrate

  • 325 mg acetaminophen, 10 mg hydrocodone bitartrate

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What Is the M365 Pill Prescribed For?

The M365 pill is prescribed for managing moderate to severe pain, often in cases where other non-opioid pain relievers such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and topical analgesics aren’t effective, such as:

  • Post-surgical pain: To manage pain following surgical procedures.

  • Injury-related pain: To treat pain relief after injuries.

  • Chronic pain conditions: Including arthritis, chronic back pain, fibromyalgia, and neuropathic pain.

Picture of white pills and a pill bottle.

M365 Pill Side Effects

Despite its uses in managing pain, the M365 pill carries potential for a range of short- and long-term side effects, including:

Short-Term Effects

  • Drowsiness and dizziness: These can affect daily activities.

  • Nausea and vomiting: Some users may experience stomach discomfort.

  • Constipation: A common issue with opioid medications.

  • Headache and dry mouth: These can occur with regular use.

Long-Term Effects

  • Tolerance and dependence: The body may require higher doses over time to achieve the same effect.

  • Addiction: There is a significant risk of developing an addiction with prolonged use.

  • Liver damage: Due to the acetaminophen component, especially if taken in higher doses than recommended.

  • Respiratory issues: Long-term use can lead to respiratory depression, a serious condition where breathing becomes inadequate.

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How Long Does the M365 Pill Take to Work?

The M365 pill typically starts to relieve pain within 30 minutes of taking it. This quick onset of action is due to the hydrocodone and acetaminophen combination, which begins to work as soon as it’s absorbed into your bloodstream.

How Long Do the Effects Last?

The effects of the M365 pill generally last between 4 to 6 hours. This duration can vary depending on factors like your metabolism, the severity of your pain, and the specific dosage prescribed by your doctor.

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How Long Does the M365 Pill Stay In Your System?

Hydrocodone, the active ingredient in the M365 pill, has a half-life of about 3 to 4 hours, meaning it takes this long for half of the drug to be metabolized and eliminated from your body. However, it can be detected in urine for up to 3 days, in blood for about 24 hours, and in hair for up to 90 days after the last dose.

Is the M365 Pill Addictive?

Yes, the M365 pill is highly addictive due to its hydrocodone content. Hydrocodone is an opioid, which can lead to physical dependence and addiction, especially with long-term use or misuse. The risk of addiction increases when the medication is taken in higher doses or more frequently than prescribed, as it can produce feelings of euphoria that contribute to its potential for abuse.

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Treatment for M365 Pill Addiction

Treating addiction to the M365 pill involves a combination of approaches to help individuals overcome dependency and lead healthier lives.Medication-assisted treatment (MAT) is often used, which includes medications that can reduce withdrawal symptoms and cravings. Alongside MAT, psychotherapy, such as cognitive-behavioral therapy (CBT), is crucial for addressing the psychological aspects of addiction.Detoxification programs also provide a safe environment for managing withdrawal symptoms, and ongoing counseling and support groups are essential for maintaining long-term recovery. These combined strategies offer a comprehensive approach to overcoming M365 pill addiction.

Closing Thoughts: The M365 Pill

The M365 pill is a prescription medication used to treat moderate to severe pain by combining hydrocodone, an opioid pain reliever, with acetaminophen, a non-opioid pain reliever. Similar brands include Norco, Vicodin, Lortab, and Lorcet, all of which contain hydrocodone and acetaminophen. While it’s effective for various pain conditions, including post-surgical pain, injury-related pain, and chronic pain conditions like arthritis and fibromyalgia, the M365 pill carries risks of dependence and addiction, especially with prolonged use.It’s important to be wary of prescription drug addiction, which is highly common and can develop over time. Remember, if you or a loved one have developed a dependence, treatment is available to help you recover.

Are You Dependent On a Prescription? We Can Help.

At The Edge Treatment Center, we specialize in prescription drug addiction, offering a team of treatment experts and a range of therapies to guide you toward recovery — and we’re here to help if you or someone you know is struggling.Call us today to learn more about our programs and start your journey to recovery.

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If you or a loved one is struggling with addiction, there is hope. Our team can guide you on your journey to recovery. Call us today.

Written by

brian-mooreBrian Moore

Content Writer

Reviewed by

jeremy-arztJeremy Arzt

Chief Clinical Officer

Drug and Alcohol

Opioid Addiction

February 6, 2023

FAQ

Frequently Asked Questions

The M365 pill typically contains a combination of acetaminophen and hydrocodone. These ingredients work together to relieve pain effectively.

No, combining the M365 pill with alcohol can increase the risk of severe side effects, including respiratory issues and liver damage. It's best to avoid alcohol while taking this medication.

Yes, the M365 pill is a prescription medication. It should only be taken under the guidance of a healthcare professional to ensure safe use.

If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed one. Do not double up on doses.

Pregnant women should avoid taking the M365 pill unless prescribed by a doctor. It may pose risks to both mother and baby.

Store the M365 pill in a cool, dry place away from light. Keep it out of reach of children to prevent accidental ingestion.

Alternatives include non-prescription medications like ibuprofen or naproxen, physical therapy, acupuncture, or other prescription pain relievers. Consult your doctor for personalized options.